Dr. Andrew Mead
PhD MRes BSc(Hons) BA(Hons)
Post-doctoral Research Assistant (Pelligand)
Department: Comparative Biomedical Sciences
Campus: Hawkshead
Research Groups: Antimicrobial Resistance
Andrew is a post-doctoral researcher whose focus is to understand and assess the impact of antimicrobial drugs through a combined microbiological and pharmacological approach.
Andrew graduated with a BSc (Hons) in Biomedical Science from the University of Bedfordshire, where he was subsequently employed as the Senior Laboratory Technician.
He obtained a MRes from the 51³Ô¹ÏÍø, funded by the Veterinary Medicines Directorate (VMD), where he established the use of dynamic hollow-fibre infection models (HFIM) to assess veterinary antimicrobial drugs. Continuing in the research area of antimicrobial therapy and pharmacology, Andrew earned his PhD from the RVC in 2022. His PhD titled “PK PD informed clinical breakpoint determination for Colistin in chicken to limit emergence of resistance and improve One Health antimicrobial sustainability” was further awarded the McKeever prize for the best original research paper related to animal health.
Currently employed as a post-doctoral researcher, Andrew continues to research the impact of human and veterinary antimicrobials to optimise dosing and explore the selection of antimicrobial resistance.
Andrew is interested in the combination of molecular, microbiological, and pharmacological approaches to understand core principles underlying antimicrobial use. He is keen to collaborate across academia and industry, and is a member of VetCAST, ENOVAT, and ECSMID.
Publications:
Mead, A., Toutain, PL., Richez, P., & Pelligand, L. (2022) Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves. Antimicrobial agents and chemotherapy. https://doi.org/10.1128/aac.00793-22
Mead, A., Billon-Lotz, C., Olsen, R., Swift, B., Richez, P., Stabler, R., & Pelligand, L. (2022). Epidemiological Prevalence of Phenotypical Resistances and Mobilised Colistin Resistance in Avian Commensal and Pathogenic E. coli from Denmark, France, The Netherlands, and the UK. Antibiotics. https://doi.org/10.3390/antibiotics11050631
Mead, A., Gillard, N., Robert, C., Pierret, G., Henrottin, J., Richez, P., & Pelligand, L. (2021) Determination of colistin in luminal and parietal intestinal matrices of chicken by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of veterinary pharmacology and therapeutics. https://doi.org/10.1111/jvp.13022
Mead, A., Richez, P., Azzariti, S., & Pelligand, L. (2021). Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli. Frontiers in Veterinary Science, 8, 634. https://doi.org/10.3389/fvets.2021.698135
Sadouki, Z., McHugh, T. D., Aarnoutse, R., Ortiz Canseco, J., Darlow, C., Hope, W., Ingen, J., Longshaw, C., Manissero, D., Mead, A., ... & Kloprogge, F. (2021). Application of the hollow fibre infection model (HFIM) in antimicrobial development: a systematic review and recommendations of reporting. Journal of Antimicrobial Chemotherapy, 76(9), 2252-2259. https://doi.org/10.1093/jac/dkab160
Mead, A., Lees, P., Mitchell, J., Rycroft, A., Standing, J., Toutain, PL., & Pelligand, L. (2019) Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannhaemia haemolytica and Pasteurella multocida in three growth media. Journal of veterinary pharmacology and therapeutics, 42(1), pp. 52-59. https://doi.org/10.1111/jvp.12719
Hofmann, S., Hardwick, N.R., Malinovskis, A., Mead, A., Greiner, J. & Guinn, B.A. (2015) Analogue peptides for the immunotherapy of acute myeloid leukaemia. Cancer Immunology, Immunotherapy, 64, 1357-67. https://doi.org/10.1007/s00262-015-1762-9
Conference presentations
Mead, A. (2022) Semi-mechanistic modelling of time-kill analysis highlights E. coli heteroresistance to colistin. Antimicrobial Agents in Veterinary Medicine (AAVM), Madrid, Spain.
Mead, A. and Pelligand, L. (2022) PK/PD informed breakpoint determination for colistin in chicken. London Pharmacometric interest group (LPIG), University College London.
Mead, A., Stabler, R., and Pelligand, L. (2021) PK/PD informed clinical breakpoint determination for colistin in chicken to limit emergence of resistance and improve One Health antimicrobial sustainability. Post-graduate research symposium, 51³Ô¹ÏÍø.
Mead, A., Richez, P., Azzariti, S., and Pelligand, L. (2020) Evaluation of colistin dosing on enteric E. coli in poultry. Antimicrobial Agents in Veterinary Medicine (AAVM), Online.
Mead, A., and Pelligand, L. (2019) Dynamic in vitro modelling: curbing the antimicrobial crisis, iBEST and School of Life sciences seminar series, University of Bedfordshire.
Mead, A., Lees, P., Rycroft, A., Standing J., Mitchell, J. & Pelligand, L. (2018) Hollow-fibre PK/PD modelling of oxytetracycline against bovine Pasteurella multocida. – ECCMID Abstract and Poster
Mead, A., Stabler, R., and Pelligand, L. (2018) PK/PD informed clinical breakpoint determination for colistin in chicken to limit emergence of resistance and improve One Health antimicrobial sustainability. Post-graduate research symposium, 51³Ô¹ÏÍø.
Mead, A., and Pelligand, L. (2018) Curbing the antimicrobial crisis through dynamic in vitro modelling. Biomedical Seminar Series, University of Hull.
Mead, A., Lees, P., Rycroft, A., Standing J., Mitchell, J. & Pelligand, L. (2017) Dynamic pharmacometrics: Hollow-fibre infection PK PD modelling of veterinary antimicrobials. Bob Michell Symposium, The 51³Ô¹ÏÍø.
Mead, A., Lees, P., Rycroft, A., Standing J., Mitchell, J. & Pelligand, L. (2017) Comparative pharmacodynamics of oxytetracycline, tetracycline and doxycycline in calf respiratory pathogens: matrix and drug effect. AAVPT, MD, USA.
Please contact Andrew if you are interested in applying for funds to work / study with him at the RVC.
Andrew is happy to be contacted regarding outreach activities / opportunities.
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Optimized dosing regimens for the combinations of sulphonamides and trimethoprim in veterinary medicine (SulTAn)
To fill the gaps related to the pharmacokinetics of Trimethoprim and Sulphonamides, and to the pharmacodynamics (PD) of their interaction on veterinary pathogens across multiple animal species.
This project will focus on the combination of different S with TMP in veterinary medicine and will aim at determining the needed adjustments or revisions to optimize TMPS dosage regimens in domestic animal species.
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PK/PD informed clinical breakpoint determination for colistin in chicken to limit emergence of resistance and improve One Health antimicrobial sustainability
This project aims to evaluate the impact of colistin use on antimicrobial resistance and rationalise dosing through a combination of in vivo pharmacokinetic (PK) dose studies, in vitro pharmacodynamic (PD) and antimicrobial susceptibility testing, and advanced in silico PK/PD modelling.
To maintain colistin as an essential antimicrobial for both human and veterinary use, recent and reliable data regarding the pharmacokinetics (PK) and pharmacodynamics (PD) at the clinical dose in poultry, and its impact on the potential selection of resistance is required to inform application and policy.